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Leadership in Aging





The Brookdale Foundation Group


Frank W. Burr Blvd

Suite 13

Teaneck, NJ









Ilhem Messaoudi, PhD

Ilhem Messaoudi

Dr. Messaoudi is Associate Pprofessor of Biomedical Science at the Unversity of California at Riverside
Research efforts in the Messaoudi laboratory are focused on three general areas: 1) the impact of age on immune response to viral infections; 2) modulation of immune function by nutritional intake and sex steroids levels; and 3) uncovering mechanisms of pathogenesis during infection with emerging and re-emerging infectious agents.

After completing graduate training at Memorial Sloan Kettering Cancer Institute and the Weill Cornell Graduate School of Medical Sciences, Dr. Messaoudi investigated how T cell clonal expansions arise in aged organisms. T cell clonal expansions are memory T cells, derived from the same T cell, that accumulate with increasing age and interfere with the generation of protective immune responses. Dr. Messaoudi also showed that caloric restriction initiated during early adulthood can delay the aging of the immune system in nonhuman primates, thereby reducing the incidence of T cell clonal expansions and improving immunity.

As a Brookdale Fellow, Dr. Messaoudi will study the impact of menopause on the aging of the immune system in older women. The goal of this project is to investigate how loss of the female sex hormones estrogen and progesterone affects T cell function and response to vaccination. Furthermore, she will investigate whether the administration of estrogen replacement therapy can delay or reverse aspects of immune senescence.

Dr. Messaoudi’s primary mentor is Henryk Urbanski, PhD, and her secondary mentor is Louis Picker, MD.

Brookdale Leadership in Aging Fellow Class of 2009